![]() ![]() We have developed narrow mechanism-specific agents targeting the intrinsic pathway of coagulation and demonstrated that experimental thrombosis and platelet production in primates is interrupted by selective inhibition of activation of coagulation factor (F)XI by FXIIa. However, a similar process can also lead to pathological processes including deep vein thrombosis, ischemic stroke, or myocardial infarction, among others. Hemostatic plug formation upon blood vessel breach is initiated by platelet recruitment, activation and aggregation in concert with thrombin generation and fibrin formation. McCarty serves as the Chair of the Biomedical Engineering Department and a fellow of the American Heart Association. McCarty joined Oregon Health & Science University in 2005, where he holds an appointment as a Professor in the Departments of Biomedical Engineering and Cell, Developmental & Cancer Biology and the Division of Hematology & Medical Oncology in the OHSU School of Medicine. He performed his postdoctoral research on platelet cell biology in the Pharmacology Department at the University of Oxford and University of Birmingham, UK in the group of Dr. degree in Chemical Engineering from Johns Hopkins University, where his research focused on the identification and characterization of tumor cell receptors for blood platelets and leukocytes. ![]() in Chemical Engineering from SUNY Buffalo, and a Ph.D. ![]()
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